诱导型一氧化氮合酶结合、S-亚硝基化并激活环氧化酶-2。
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
作者信息
Kim Sangwon F, Huri Daniel A, Snyder Solomon H
机构信息
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
出版信息
Science. 2005 Dec 23;310(5756):1966-70. doi: 10.1126/science.1119407.
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
环氧化酶-2（COX-2）和诱导型一氧化氮合酶（iNOS）是两种主要的炎症介质。在此我们表明，iNOS特异性结合COX-2并使其S-亚硝基化，增强COX-2的催化活性。选择性破坏iNOS-COX-2的结合可阻止NO介导的COX-2激活。这两种炎症系统之间的协同分子相互作用可能为抗炎药物的开发提供思路。
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