Lal Devyani, Baroody Fuad M, Weitzel Eric K, deTineo Marcy, Naclerio Robert M
Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, IL 60637, USA.
Int Arch Allergy Immunol. 2006;139(2):146-8. doi: 10.1159/000090390. Epub 2005 Dec 21.
Total IgE levels positively correlate with the amount of mucosal thickening on sinus CT scans. Our objective was to investigate whether the levels of total serum IgE decreased 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis, suggesting that the total IgE was influenced by the sinus disease.
55 patients about to undergo endoscopic sinus surgery for chronic rhinosinusitis were enrolled in a prospective clinical study. All patients had preoperative sinus computerized tomography (CT) scans and levels of total serum IgE measured before surgery and 1 year postoperatively.
Preoperative total IgE levels showed a significant correlation with the extent of disease on sinus CT (r(s) = 0.413, p = 0.002). Total serum IgE levels did not show any statistically significant change from the preoperative values when measured 1 year postoperatively (324.25 +/- 217.30 ng/ml vs. 326.35 +/- 204.50 ng/ml; p = 0.61).
The levels of total serum IgE do not change after sinus surgery for chronic rhinosinusitis. IgE levels in chronic rhinosinusitis may reflect a systemic factor in disease pathogenesis, and are probably not related to the amount of local inflammation within the sinuses.
血清总IgE水平与鼻窦CT扫描中黏膜增厚程度呈正相关。我们的目的是调查慢性鼻窦炎患者在内镜鼻窦手术后1年血清总IgE水平是否下降，这表明总IgE受鼻窦疾病影响。
55例即将接受慢性鼻窦炎内镜鼻窦手术的患者纳入一项前瞻性临床研究。所有患者术前均进行鼻窦计算机断层扫描（CT），并在手术前及术后1年测量血清总IgE水平。
术前总IgE水平与鼻窦CT上的疾病范围呈显著相关（r(s)=0.413，p=0.002）。术后1年测量时，血清总IgE水平与术前值相比无统计学显著变化（324.25±217.30 ng/ml对326.35±204.50 ng/ml；p=0.61）。
慢性鼻窦炎鼻窦手术后血清总IgE水平不变。慢性鼻窦炎中的IgE水平可能反映了疾病发病机制中的一个全身因素，可能与鼻窦内局部炎症程度无关。
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