Bhattacharyya Neil
Division of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):167-71. doi: 10.1097/01.all.0000225154.45027.a4.
Chronic rhinosinusitis continues to present diagnostic and therapeutic challenges for clinicians. Recently, attention has been focused on reliable and valid measures of outcomes for many sinonasal diseases. As a significant fraction of patients with chronic rhinosinusitis will come to endoscopic sinus surgery, there has been a dedicated focus on determining objective clinical outcomes after medical and surgical treatment for CRS. This has been aided by validated instruments for measuring both symptom outcomes and quality of life after endoscopic sinus surgery.
Recent studies have demonstrated that endoscopic sinus surgery provides statistically and clinically significant improvements in most sinonasal symptoms. These benefits are maintained more than 1 year after surgery. In addition, the significant adverse effects of chronic rhinosinusitis on quality of life can be reversed with appropriate endoscopic sinus surgery. Certain sub-populations do not fare as well with endoscopic sinus surgery, however; adjunctive medical management is required to maintain symptomatic and quality-of-life improvements for patients with nasal polyposis. Unfortunately, paranasal sinus computed tomography scan findings do not predict symptomatic or quality-of-life improvements after endoscopic sinus surgery.
With reliable objective evidence of the health benefits of endoscopic sinus surgery, patients should be considered for such surgery after failure of medical management. Further work is required to characterize outcomes for sub-populations, and to stage and select patients who will derive appropriate benefit from endoscopic sinus surgery.
慢性鼻-鼻窦炎仍然给临床医生带来诊断和治疗方面的挑战。最近,人们的注意力集中在许多鼻窦疾病的可靠且有效的疗效评估指标上。由于相当一部分慢性鼻-鼻窦炎患者会接受鼻内镜鼻窦手术,因此一直致力于确定慢性鼻-鼻窦炎药物和手术治疗后的客观临床疗效。这得益于用于测量鼻内镜鼻窦手术后症状疗效和生活质量的经过验证的工具。
最近的研究表明,鼻内镜鼻窦手术在大多数鼻窦症状方面能带来统计学和临床上的显著改善。这些益处术后能维持1年以上。此外,慢性鼻-鼻窦炎对生活质量的显著不良影响可通过适当的鼻内镜鼻窦手术得到逆转。然而,某些亚组患者接受鼻内镜鼻窦手术的效果不佳;对于鼻息肉患者,需要辅助药物治疗以维持症状改善和生活质量提升。不幸的是,鼻窦计算机断层扫描结果无法预测鼻内镜鼻窦手术后的症状或生活质量改善情况。
有可靠的客观证据表明鼻内镜鼻窦手术对健康有益,药物治疗失败后应考虑让患者接受此类手术。需要进一步开展工作,以明确亚组患者的疗效特征,并对能从鼻内镜鼻窦手术中获得适当益处的患者进行分期和选择。