[Significance of the changes of urinary uric acid in OSAHS before and after UPPP].

OBJECTIVE

To assess the value of urinary uric acid excretion and urinary uric acid/creatinine ratio as the marker of obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after Uvulopalatopharyngoplasty (UPPP).

METHOD

Twenty three cases diagnosed as OSAHS by polysomnography (PSG) were treated as trial group, 12 cases excluded from OSAHS by PSG were taken as control group,and 15 patients of the trial group were treated by UPPP and were taken as before UPPP therapy group and after UPPP therapy group. The makers above were compared in these groups.

RESULT

The overnight change in urinary uric acid/creatinine ratio in trial group is 0.46+/-0.25, and after UPPP therapy group (0.13+/-0.2) significantly lower than before UPPP therapy group (0.49 +/-0.32), P < 0.01.

CONCLUSION

The urinary uric acid excretion and overnight change in urinary uric acid/creatinine are good markers to determine the effects of UPPP on OSAHS.