Kaur Surinder, Uddin Shahab, Platanias Leonidas C
Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, 303 East Superior Street, Chicago, IL 60611, USA.
J Interferon Cytokine Res. 2005 Dec;25(12):780-7. doi: 10.1089/jir.2005.25.780.
Interferons (IFNs) are pleiotropic cytokines with important immunomodulatory, antitumor, antiviral, and growth inhibitory properties. Consistent with the multiplicity of their effects, the IFNs activate several cellular cascades after they bind to their receptors. Although the Jak-Stat pathway is the most studied pathway, it appears that additional signaling cascades play roles in IFN signaling. The phosphatidylinositol 3'-kinase (PI3'K) pathway has emerged as one of the critical players in IFN signal transduction and is the focus of this review. This pathway is activated distinctively from the Stat pathway but plays important roles in the regulation of IFN-dependent gene transcription and initiation of mRNA translation.
干扰素（IFNs）是具有重要免疫调节、抗肿瘤、抗病毒和生长抑制特性的多效性细胞因子。与其多种效应相一致，干扰素在与受体结合后会激活多个细胞级联反应。尽管Jak-Stat途径是研究最多的途径，但似乎其他信号级联反应也在干扰素信号传导中发挥作用。磷脂酰肌醇3'-激酶（PI3'K）途径已成为干扰素信号转导中的关键参与者之一，也是本综述的重点。该途径的激活方式与Stat途径不同，但在干扰素依赖性基因转录的调节和mRNA翻译的起始中发挥重要作用。
