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Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

作者信息

Pérez-Pérez María-Jesús, Priego Eva-María, Hernández Ana-Isabel, Camarasa María-José, Balzarini Jan, Liekens Sandra

机构信息

Instituto de Química Médica (CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.

出版信息

Mini Rev Med Chem. 2005 Dec;5(12):1113-23. doi: 10.2174/138955705774933301.

DOI:10.2174/138955705774933301
PMID:16375757
Abstract

Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF), stimulates endothelial cell migration in vitro and angiogenesis in vivo and plays an important role in tumour progression and metastasis. Here we have summarized the most recent approaches in the search for novel TPase inhibitors together with the potential therapeutic applications of such inhibitors.

摘要

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