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合欢树胶作为片剂制剂粘合剂的评估

Assessment of Albizia zygia gum as a binding agent in tablet formulations.

作者信息

Odeku Oluwatoyin A

机构信息

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy University of Ibadan, Ibadan, Nigeria.

出版信息

Acta Pharm. 2005 Sep;55(3):263-76.

Abstract

Albizia gum has been evaluated as a binding agent in tablet formulations in comparison with gelatin BP. Compressional properties were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters, while the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets. Drug release properties of the tablets were assessed using disintegration time and dissolution time as assessment parameters. Formulations containing Albizia gum as a binding agent show a faster onset and higher amount of plastic deformation under compression pressure than those containing gelatin. The crushing strength, disintegration and dissolution times of the tablets increased with increased binder concentration while their friability decreased. Albizia gum produced tablets with better mechanical properties and longer disintegration and dissolution times than those containing gelatin BP. This suggests that Albizia gum could be useful as a binding agent especially when high mechanical strength and slower release rates are desired.

摘要

与明胶BP相比,合欢胶已被评估为片剂配方中的粘合剂。使用密度测量以及Heckel和Kawakita压缩方程作为评估参数来分析压缩性能,同时使用片剂的抗压强度和脆碎度来评估片剂的机械性能。使用崩解时间和溶出时间作为评估参数来评估片剂的药物释放特性。与含有明胶的制剂相比,含有合欢胶作为粘合剂的制剂在压缩压力下显示出更快的起效和更高的塑性变形量。片剂的抗压强度、崩解和溶出时间随粘合剂浓度的增加而增加,而其脆碎度降低。与含有明胶BP的片剂相比,合欢胶制成的片剂具有更好的机械性能以及更长的崩解和溶出时间。这表明合欢胶可作为一种粘合剂,特别是当需要高机械强度和较慢释放速率时。

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