De Biplab, Gupta Jayanta Kumar, Saravanan Venkatapuram Sampath
Regional Institute of Pharmaceutical Science & Technology, Abhoynagar Agartala, Tripura-799005, India.
Acta Pharm. 2005 Sep;55(3):287-96.
A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phe- nyl-4-acetylidene/benzylidene-imidazolin-5[4H]-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5[4H]-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imi- dazolin-5[4H]-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.
从相应的乙炔基/亚苄基恶唑啉酮新合成了几种咪唑啉酮类化合物[1-氨基乙基/苯基-2-甲基/苯基-4-乙炔基/亚苄基-咪唑啉-5[4H]-酮]。通过咪唑啉酮与苯甲醛反应合成了席夫碱。几乎所有化合物的抗菌筛选结果显示，它们对枯草芽孢杆菌ATCC 6633和肺炎克雷伯菌ATCC 25063具有中度到显著的活性。化合物10[1-氨基苯基-2-苯基-4-乙炔基-咪唑啉-5[4H]-酮]和12[1-氨基苯基-2-苯基-4-亚苄基-咪唑啉-5[4H]-酮]对白色念珠菌ATCC 29738的活性甚至比两性霉素B更好。
