帕金森病中的运动并发症及大鼠旋转行为的临床意义：我们是否在浪费时间？ - Suppr

Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time?

作者信息

Marin C, Rodriguez-Oroz M C, Obeso J A

机构信息

Laboratori de Neurologia Experimental, Fundació Clínic-Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, IDIBAPS, Barcelona, Spain.

出版信息

Exp Neurol. 2006 Feb;197(2):269-74. doi: 10.1016/j.expneurol.2005.11.002. Epub 2005 Dec 22.

DOI:10.1016/j.expneurol.2005.11.002

PMID:16375892

Abstract

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Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time?帕金森病中的运动并发症及大鼠旋转行为的临床意义：我们是否在浪费时间？

Exp Neurol. 2006 Feb;197(2):269-74. doi: 10.1016/j.expneurol.2005.11.002. Epub 2005 Dec 22.

Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease?6-羟基多巴胺损伤大鼠中的反向旋转是否表明其具有诱发帕金森病运动并发症以及治疗效果的能力？

Exp Neurol. 2006 Feb;197(2):284-90. doi: 10.1016/j.expneurol.2005.06.006. Epub 2005 Jul 11.

Compromised circadian function in Parkinson's disease: enucleation augments disease severity in the unilateral model.帕金森病中昼夜节律功能受损：在单侧模型中摘除眼球会加重疾病严重程度。

Behav Brain Res. 2008 Nov 3;193(1):37-47. doi: 10.1016/j.bbr.2008.04.017. Epub 2008 Apr 26.

Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease.在帕金森病大鼠模型中，表达神经营养因子的C17.2神经干细胞对多巴胺能神经元的神经保护作用。

Parkinsonism Relat Disord. 2007 Mar;13(2):77-88. doi: 10.1016/j.parkreldis.2006.07.015. Epub 2006 Sep 11.

Generation of a alpha-synuclein-based rat model of Parkinson's disease.基于α-突触核蛋白的帕金森病大鼠模型的建立。

Neurobiol Dis. 2008 Apr;30(1):8-18. doi: 10.1016/j.nbd.2007.11.002. Epub 2007 Nov 13.

The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat.5-羟色胺（1A）受体刺激对多巴胺受体介导的异动症及启动的偏侧帕金森病大鼠旋转行为的不同影响

Brain Res. 2007 Jul 16;1158:135-43. doi: 10.1016/j.brainres.2007.05.005. Epub 2007 May 8.

The 6-hydroxydopamine model: news from the past.6-羟基多巴胺模型：来自过去的消息。

Parkinsonism Relat Disord. 2008;14 Suppl 2:S124-9. doi: 10.1016/j.parkreldis.2008.04.015. Epub 2008 Jul 2.

Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice.野生型和α-突触核蛋白缺失小鼠中帕金森病纹状体6-羟基多巴胺模型的特征

Exp Neurol. 2008 Mar;210(1):182-93. doi: 10.1016/j.expneurol.2007.10.012. Epub 2007 Nov 1.

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease.在帕金森病大鼠模型中进行神经移植后，苯丙胺诱导的异常运动独立于移植和宿主来源的5-羟色胺神经支配而发生。

Neurobiol Dis. 2009 Jul;35(1):42-51. doi: 10.1016/j.nbd.2009.03.014. Epub 2009 Apr 8.

Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease.在帕金森病单侧6-羟基多巴胺大鼠模型中，垂直行为期间的性二态姿势调整发生改变。

Behav Brain Res. 2006 Nov 1;174(1):39-48. doi: 10.1016/j.bbr.2006.07.004. Epub 2006 Aug 22.

引用本文的文献

Simultaneous Measurement of Striatal Dopamine and Hydrogen Peroxide Transients Associated with L-DOPA Induced Rotation in Hemiparkinsonian Rats.同时测量偏侧帕金森病大鼠中与左旋多巴诱导旋转相关的纹状体多巴胺和过氧化氢瞬变

ACS Meas Sci Au. 2021 Nov 8;2(2):120-131. doi: 10.1021/acsmeasuresciau.1c00030. eCollection 2022 Apr 20.

The Rodent Models of Dyskinesia and Their Behavioral Assessment.运动障碍的啮齿动物模型及其行为评估。

Front Neurol. 2019 Oct 11;10:1016. doi: 10.3389/fneur.2019.01016. eCollection 2019.

Monoamine reuptake inhibitors in Parkinson's disease.单胺再摄取抑制剂在帕金森病中的应用。

Parkinsons Dis. 2015;2015:609428. doi: 10.1155/2015/609428. Epub 2015 Feb 25.

Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models.突触后致密蛋白95调节左旋多巴诱导的异动症大鼠模型中NR2B的酪氨酸磷酸化及Fyn与NR2B的相互作用。

Drug Des Devel Ther. 2014 Dec 19;9:199-206. doi: 10.2147/DDDT.S75495. eCollection 2015.

Spontaneous locomotor activity and L-DOPA-induced dyskinesia are not linked in 6-OHDA parkinsonian rats.在6-羟基多巴胺诱导的帕金森病大鼠中，自发运动活性与左旋多巴诱发的运动障碍并无关联。

Front Behav Neurosci. 2014 Oct 2;8:331. doi: 10.3389/fnbeh.2014.00331. eCollection 2014.

Modeling Parkinson's disease in monkeys for translational studies, a critical analysis.为转化研究建立猴帕金森病模型：批判性分析。

Exp Neurol. 2014 Jun;256:133-43. doi: 10.1016/j.expneurol.2013.09.014. Epub 2013 Sep 23.

Counteraction by nitric oxide synthase inhibitor of neurochemical alterations of dopaminergic system in 6-OHDA-lesioned rats under L-DOPA treatment.一氧化氮合酶抑制剂对左旋多巴治疗的 6-OHDA 损伤大鼠多巴胺能系统神经化学改变的拮抗作用。

Neurotox Res. 2014 Jan;25(1):33-44. doi: 10.1007/s12640-013-9406-3. Epub 2013 Jun 27.

An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease.在帕金森病前驱期大鼠模型中，NR2B 依赖性 trkB 受体表达减少先于黑质多巴胺能神经元消失。

Parkinsons Dis. 2012;2012:129605. doi: 10.1155/2012/129605. Epub 2012 Jun 7.

Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements.纹状体中 DeltaFosB 的过度表达可再现慢性左旋多巴诱导的不自主运动。

J Neurosci. 2010 May 26;30(21):7335-43. doi: 10.1523/JNEUROSCI.0252-10.2010.

Effect of the metabotropic glutamate antagonist MPEP on striatal expression of the Homer family proteins in levodopa-treated hemiparkinsonian rats.代谢型谷氨酸拮抗剂MPEP对左旋多巴治疗的偏侧帕金森病大鼠纹状体中荷马家族蛋白表达的影响。

Psychopharmacology (Berl). 2009 Oct;206(2):233-42. doi: 10.1007/s00213-009-1600-x. Epub 2009 Jul 28.

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Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time?

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