[1987 - 1999年罗纳-阿尔卑斯地区儿科登记处儿童癌症发病率和生存率]

[Childhood cancer incidence and survival rates in the Rhône-Alpes regional paediatric registry 1987-1999].

作者信息

Berger C, Trombert-Paviot B, Mitton N, Frappaz D, Galambrun C, Plantaz D, Dupuis S, Bertrand Y, Philippe N, Schell M, Marec-Bérard P, Bergeron C, Armari-Alla C, Pagnier A, Stephan J L, Freycon F

机构信息

Unité d'Hémato-Oncologie Pédiatrique, Institut de Cancérologie de la Loire,42270 Saint-Priest-en-Jarez, France.

出版信息

Arch Pediatr. 2006 Feb;13(2):121-9. doi: 10.1016/j.arcped.2005.10.022. Epub 2006 Jan 11.

DOI:10.1016/j.arcped.2005.10.022

PMID:16376530

Abstract

UNLABELLED

Cancer is rare in children, and pediatric malignancies represent only 1% of all cancers.

OBJECTIVES

The cure rate is high and increasing, and ongoing data collection is therefore warranted.

MATERIALS AND METHODS

Here we report the incidence and survival rates of childhood cancers between 1987 and 1999 in the Rhône-Alpes region of France.

RESULTS

A total of 1945 cases were recorded during the study period, with an average of 149.6 new cases per year. The approximate incidence rate was 134.1/10(6) per year and the age-standardized incidence rate was 139.2/10(6) per year. The histological distribution and 5-year survival rates were respectively 30.2 and 73% for leukemia, 12.3 and 91.6% for lymphoma, 24.7 and 60.1% for CNS tumors, 9.1 and 71.1% for neuroblastoma, 2.5 and 94.1% for retinoblastoma, 5.8% and 89.9% for renal tumors, 1 and 75% for liver tumors, 6.1 and 60.9% for bone tumors, 4.1 and 58.6% for soft-tissue tumors, 1.1 and 71% for germ cell tumors, and 2.4 and 85.1% for carcinomas.

CONCLUSION

The overall survival rate was 75%. Long-term treatment complications warrant further studies of children who survive into adulthood.

摘要

未标注

癌症在儿童中较为罕见，儿童恶性肿瘤仅占所有癌症的1%。

目的

治愈率高且呈上升趋势，因此有必要持续收集数据。

材料与方法

在此我们报告法国罗纳-阿尔卑斯地区1987年至1999年间儿童癌症的发病率和生存率。

结果

研究期间共记录了1945例病例，平均每年有149.6例新发病例。年发病率约为134.1/10⁶，年龄标准化发病率为139.2/10⁶。白血病的组织学分布和5年生存率分别为30.2%和73%，淋巴瘤为12.3%和91.6%，中枢神经系统肿瘤为24.7%和60.1%，神经母细胞瘤为9.1%和71.1%，视网膜母细胞瘤为2.5%和94.1%，肾肿瘤为5.8%和89.9%，肝肿瘤为1%和75%，骨肿瘤为6.1%和60.9%，软组织肿瘤为4.1%和58.6%，生殖细胞肿瘤为1.1%和71%，癌为2.4%和85.1%。