Lieb Jason D, Clarke Neil D
Department of Biology and the Carolina Center for Genome Sciences, 202 Fordham Hall, CB 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cell. 2005 Dec 29;123(7):1187-90. doi: 10.1016/j.cell.2005.12.010.
Several recent papers show that differences in histone modification and the use of histone variants at the 5' and 3' ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls access to DNA at specific genomic locations.
最近的几篇论文表明,基因5'端和3'端的组蛋白修饰差异以及组蛋白变体的使用会影响转录起始的位置和动力学。大多数表观遗传机制的最终目标可能是对核小体占据情况的调控,而这反过来又控制着特定基因组位置对DNA的可及性。