Metzelaar-Blok J A W, Hurks H M H, Naipal A, De Lange P, Keunen J E E, Claas F H J, Doxiadis I I N, Jager M J
Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Mol Vis. 2005 Dec 21;11:1166-72.
The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility contributed by HLA class I, class II, or MICA genes with regard to the development of uveal melanoma.
Between 1998 and 2001, 159 uveal melanoma patients were typed for HLA class I and II, and 168 uveal melanoma patients were evaluated for MICA by microsatellite typing. The HLA antigen and MICA allele frequencies were compared with control groups of, respectively, 2,440 and 247 healthy Dutch individuals.
HLA class I, HLA class II, and MICA gene frequencies in uveal melanoma patients and healthy Dutch controls showed no significant deviations after correction for the number of comparisons.
We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma.
HLA I类和II类分子以及MHC I类链相关基因A（MICA，一种多态性且受应激诱导的细胞表面分子）的分子参与T细胞和自然杀伤细胞（NK细胞）介导的免疫反应。在本研究中，我们探究了HLA I类、II类或MICA基因对葡萄膜黑色素瘤发生发展的遗传易感性。
1998年至2001年间，对159例葡萄膜黑色素瘤患者进行了HLA I类和II类分型，对168例葡萄膜黑色素瘤患者通过微卫星分型评估MICA。将HLA抗原和MICA等位基因频率分别与2440例和247例荷兰健康个体的对照组进行比较。
校正比较次数后，葡萄膜黑色素瘤患者和荷兰健康对照中的HLA I类、HLA II类和MICA基因频率无显著差异。
我们得出结论，就葡萄膜黑色素瘤的发生发展而言，任何HLA I类、II类和MICA多态性均未导致遗传易感性增加或风险升高。
