血清素转运体基因调控区多态性与焦虑之间关联的性别差异。
Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.
作者信息
Mizuno Tomoko, Aoki Masashi, Shimada Yuko, Inoue Midori, Nakaya Kumi, Takahashi Toshiaki, Itoyama Yasuto, Kanazawa Motoyori, Utsumi Atsushi, Endo Yuka, Nomura Taisuke, Hiratsuka Masahiro, Mizugaki Michinao, Goto Junichi, Hongo Michio, Fukudo Shin
机构信息
Tohoku University Graduate School of Medicine, Sendai, Japan.
出版信息
J Psychosom Res. 2006 Jan;60(1):91-7. doi: 10.1016/j.jpsychores.2005.06.068.
OBJECTIVE
The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress.
METHODS
Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS).
RESULTS
There was significant GenderxGenotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype.
CONCLUSION
On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.
目的
本研究的目的是验证血清素转运体基因启动子区域（5-HTTLPR）的变异与应激敏感性相关这一假设。
方法
对194名参与者进行5-HTTLPR基因分型和情绪状态评估。使用感知压力量表（PSS）、状态-特质焦虑量表（STAI）和自评抑郁量表（SDS）对参与者的情绪状态进行评估。
结果
在STAI中存在显著的性别×基因型交互作用（状态，P<.05；特质，P<.05）。在状态焦虑和特质焦虑方面，携带l/s基因型的女性比携带s/s基因型的女性表现出更高的焦虑水平。相反，携带s/s基因型的男性比携带l/s基因型的男性表现出更高的焦虑水平。
结论
在所有情绪量表上，携带l/s基因型的女性得分较高，这与具有相同基因型的男性相反。因此，我们的结果表明，5-HTTLPR l等位基因可能是激活女性负面情绪的一条途径，但在男性中作用相反。
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