Veletza Stavroula, Samakouri Maria, Emmanouil George, Trypsianis Gregory, Kourmouli Niki, Livaditis Miltiadis
Department of Biology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Synapse. 2009 Mar;63(3):193-200. doi: 10.1002/syn.20598.
To study the effect of the serotonin transporting gene L/S polymorphism on several psychological characteristics in a group of Greek University students.
One hundred eighty-one students were genotyped and classified into two groups: carriers or noncarriers of an S allele. Students were evaluated with a battery of psychological tests (Zung depression rating scale, symptoms check-list-90-R, Eysenck personality inventory); they also answered questionnaires regarding serious past adverse experiences as well as nicotine and alcohol use. Multivariate analysis of variance (MANOVA) was used to check the main effect of genotype and its interaction with both adverse life experiences and scores of psychological tests.
No significant differences were detected between the two groups of students regarding scores of the psychological tests. Yet, analysis with MANOVA indicated an interaction between genotype and adversities (lambda = 0.838, F(17,158) = 1.802, P = 0.032). Students who both carry at least one S allele and have faced serious past adverse life experiences have scored higher than carriers of the S allele who have not faced adversities on the following: global severity index (F(1174) = 5.973, P = 0.016), positive symptoms distress index (F(1174) = 4.518, P = 0.035), somatization (F(1174) = 4.074, P = 0.045), depression (F(1174) = 4.971, P = 0.027), anxiety (F(1174) = 8.112, P = 0.005), phobic anxiety (F(1174) = 16.421, P < 0.000), and paranoid ideation (F(1174) = 5.143, P = 0.025). Among students without adversities, those with the LL genotype have scored higher than S allele carriers on the following: depression (t = 2.680, df = 75, P = 0.009), anxiety (t = 2.629, df = 75, P = 0.010), phobic anxiety (t = 3.350, df = 75, P = 0.001), and paranoid ideation (t = 2.668, df = 75, P = 0.009).
The S and L alleles seem to interact differently with serious past life adversities in influencing psychological vulnerability. Adversities seem to have a stronger effect on S carriers. LL genotype might be related to the expression of certain more endogenous psychopathological tendencies.
研究血清素转运基因L/S多态性对一组希腊大学生若干心理特征的影响。
对181名学生进行基因分型，并分为两组：S等位基因携带者或非携带者。学生们接受了一系列心理测试（zung抑郁自评量表、症状自评量表-90-R、艾森克人格问卷）；他们还回答了关于过去严重不良经历以及尼古丁和酒精使用情况的问卷。采用多变量方差分析（MANOVA）来检验基因型的主要效应及其与不良生活经历和心理测试分数的相互作用。
两组学生在心理测试分数方面未检测到显著差异。然而，MANOVA分析表明基因型与逆境之间存在相互作用（λ=0.838，F(17,158)=1.802，P=0.032）。那些至少携带一个S等位基因且过去曾面临严重不良生活经历的学生在以下方面的得分高于未面临逆境的S等位基因携带者：总体严重程度指数（F(1,174)=5.973，P=0.016）、阳性症状痛苦指数（F(1,174)=4.518，P=0.035）、躯体化（F(1,174)=4.074，P=0.045）、抑郁（F(1,174)=4.971，P=0.027）、焦虑（F(1,174)=8.112，P=0.005）、恐惧焦虑（F(1,174)=16.421，P<0.000）和偏执观念（F(1,174)=5.143，P=0.025）。在没有逆境的学生中，LL基因型的学生在以下方面的得分高于S等位基因携带者：抑郁（t=2.680，自由度=75，P=0.009）、焦虑（t=2.629，自由度=75，P=0.010）、恐惧焦虑（t=3.350，自由度=75，P=...
