Hashimoto Tomoko, Uchida Kenichiro, Okayama Naoko, Imate Yuji, Suehiro Yutaka, Hamanaka Yuichiro, Ueyama Yoshiya, Yamashita Hiroshi, Hinoda Yuji
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Mol Carcinog. 2006 May;45(5):344-8. doi: 10.1002/mc.20140.
Recent molecular epidemiological studies have demonstrated that the human oxoguanine glycosylase 1 (OGG1) gene polymorphism may be associated with various cancers. To determine whether the OGG1 Ser326Cys polymorphism interacts with clinicopathological parameters including smoking and alcohol intake in head and neck squamous cell carcinoma (HNSCC), DNA samples from 192 patients with primary HNSCC were genotyped and studied by the case-only design. We observed an association between the Cys/Cys genotype and HNSCC with cigarette smoking of more than 40 pack-years by a multivariate logistic regression analysis (OR=8.10, 95% CI=1.06-61.73). No significant association of this genotype with alcohol intake was observed. Our present data suggest a possible interaction between the OGG1 Ser326Cys polymorphism and smoking in HNSCC.
近期的分子流行病学研究表明，人类8-氧鸟嘌呤糖基化酶1（OGG1）基因多态性可能与多种癌症相关。为了确定OGG1 Ser326Cys多态性是否与头颈部鳞状细胞癌（HNSCC）的临床病理参数（包括吸烟和饮酒）相互作用，我们采用病例对照研究设计，对192例原发性HNSCC患者的DNA样本进行基因分型和研究。通过多因素逻辑回归分析，我们观察到Cys/Cys基因型与吸烟量超过40包年的HNSCC之间存在关联（OR=8.10，95%CI=1.06-61.73）。未观察到该基因型与饮酒之间存在显著关联。我们目前的数据表明，OGG1 Ser326Cys多态性与HNSCC中的吸烟之间可能存在相互作用。
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