Sørensen Mette, Raaschou-Nielsen Ole, Hansen Rikke D, Tjønneland Anne, Overvad Kim, Vogel Ulla
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Free Radic Res. 2006 Aug;40(8):885-91. doi: 10.1080/10715760600733129.
The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs oxidatively damaged DNA and a polymorphism in the OGG1 gene (Ser326Cys) has been associated with lung cancer. We examined associations between the polymorphism and intake of fruits and vegetables and smoking in the development of lung cancer, by genotyping blood samples from 431 lung cancer cases and 796 comparison persons, which were identified within a prospective cohort on 57,000 cohort members. We found no overall association between the OGG1 polymorphism and lung cancer. There was a statistically significant interaction between the polymorphism and dietary intake of vegetables, with a 54% decrease in lung cancer risk per 50% increase in vegetable intake among homozygous Cys326Cys carriers and no decrease in risk among carriers of Ser326Ser or Ser326Cys. The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking.
8-氧代鸟嘌呤糖基化酶1（OGG1）可修复氧化损伤的DNA，OGG1基因中的一个多态性位点（Ser326Cys）与肺癌相关。我们通过对431例肺癌病例和796名对照者的血样进行基因分型，研究了该多态性与水果和蔬菜摄入量以及吸烟在肺癌发生中的关联，这些病例和对照者来自一个57000名队列成员的前瞻性队列。我们发现OGG1多态性与肺癌之间无总体关联。该多态性与蔬菜的饮食摄入量之间存在统计学显著的交互作用，对于纯合Cys326Cys携带者，蔬菜摄入量每增加50%，肺癌风险降低54%，而Ser326Ser或Ser326Cys携带者的风险无降低。水果摄入量方面也呈现相同趋势。OGG1多态性与吸烟之间无统计学显著的交互作用。
