[Comparative characteristic of structural-functional changes of the spleen in the offspring of female rats with chronic liver pathology of various etiology].

The aim of the study was a comparative analysis of structural-functional changes of the spleen in the offspring of female rats with chronic liver pathology of various genesis. In adult female Wistar rats various forms of liver lesions were modeled: toxic, autoimmune, cholestatic. The spleen of the offspring of the experimental animals with chronic liver disease was studied at different time points of postnatal ontogenesis. The increased numbers of Ig-producing cells and splenic karyocytes were detected in association with an increased surface area of the section, occupied by lymphoid nodules. Activation of proliferation and differentiation of B-lymphocytes was found together with an increase of the surface area of the section, occupied by B-dependent zones, indicating the increased intensity of humoral immunity in the offspring of female rats with chronic pathology of hepatobiliary system of various genesis.