第三脑室前腹侧室周核损伤会降低对下丘脑腹内侧核激活的升压、饮水和利钠反应。

AV3V lesion reduces the pressor, dipsogenic, and natriuretic responses to ventromedial hypothalamus activation.

作者信息

Valladão A S, Saad W A, Camargo L A, Renzi A, de Luca Júnior L A, Menani J V

机构信息

Department of Physiology, School of Dentistry, Paulista State University, Araraquara, SP, Brazil.

出版信息

Brain Res Bull. 1992 Jun;28(6):909-14. doi: 10.1016/0361-9230(92)90211-f.

DOI:10.1016/0361-9230(92)90211-f

PMID:1638417

Abstract

In the present study, we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, tachycardic, dipsogenic, natriuretic, and kaliuretic responses induced by the injection of the cholinergic agonist carbachol into the ventromedial hypothalamic nucleus (VMH) of rats. Male rats with sham or AV3V lesion and a stainless steel cannula implanted into the VMH were used. Carbachol (2 nmol) injected into the VMH of sham rats produced pressor (32 +/- 4 mmHg), tachycardic (83 +/- 14 bpm), dipsogenic (8.2 +/- 1.1 ml/h), natriuretic (320 +/- 46 microEq/120 min), and kaliuretic (155 +/- 20 microEq/120 min) responses. In AV3V-lesioned rats (2 and 15 days), the pressor (4 +/- 2 and 15 +/- 2 mmHg, respectively), dipsogenic (0.3 +/- 0.2 and 1.4 +/- 0.7 ml/h), natriuretic (17 +/- 7 and 99 +/- 21 microEq/120 min), and kaliuretic (76 +/- 14 and 79 +/- 7 microEq/120 min) responses induced by carbachol injection into the VMH were reduced. The tachycardia was also abolished (27 +/- 15 and -23 +/- 29 bpm, respectively). These results show that the AV3V region is essential for the pressor, tachycardic, dipsogenic, natriuretic, and kaliuretic responses induced by cholinergic activation of the VMH in rats.

摘要

在本研究中，我们调查了大鼠腹内侧下丘脑核（VMH）注射胆碱能激动剂卡巴胆碱所诱导的升压、心动过速、饮水、利钠和利尿反应，观察了前腹侧第三脑室（AV3V）损伤对此的影响。选用雄性大鼠，分别进行假手术或AV3V损伤，并将不锈钢套管植入VMH。向假手术大鼠的VMH注射卡巴胆碱（2 nmol）可产生升压反应（32±4 mmHg）、心动过速反应（83±14次/分钟）、饮水反应（8.2±1.1 ml/h）、利钠反应（320±46微当量/120分钟）以及利尿反应（155±20微当量/120分钟）。在AV3V损伤的大鼠中（损伤后2天和15天），向VMH注射卡巴胆碱所诱导的升压反应（分别为4±2和15±2 mmHg）、饮水反应（0.3±0.2和1.4±0.7 ml/h）、利钠反应（17±7和99±21微当量/120分钟）以及利尿反应（76±14和79±7微当量/120分钟）均减弱。心动过速反应也消失了（分别为27±15和-23±29次/分钟）。这些结果表明，AV3V区域对于大鼠VMH胆碱能激活所诱导的升压、心动过速、饮水、利钠和利尿反应至关重要。