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Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.咪唑并[1,2 - a]吡嗪 - 8 - 酮、咪唑并[1,2 - d][1,2,4]三嗪 - 8 - 酮和咪唑并[2,1 - f][1,2,4]三嗪 - 8 - 酮作为α2/α3亚型选择性GABA A激动剂用于治疗焦虑症。

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1582-5. doi: 10.1016/j.bmcl.2005.12.027. Epub 2005 Dec 27.

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Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.咪唑并[1,2-a]嘧啶作为功能选择性且口服生物可利用的GABA(A)α2/α3结合位点激动剂用于治疗焦虑症。

J Med Chem. 2006 Jan 12;49(1):35-8. doi: 10.1021/jm051065l.

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A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.用于治疗焦虑症的哒嗪系列α2/α3亚型选择性GABA A激动剂。

J Med Chem. 2006 Apr 20;49(8):2600-10. doi: 10.1021/jm051144x.

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Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.咪唑并[1,2 - b][1,2,4]三嗪作为α2/α3亚型选择性GABA A激动剂用于治疗焦虑症。

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1477-80. doi: 10.1016/j.bmcl.2005.12.044. Epub 2006 Jan 4.

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Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.发现咪唑并[1,2 - b][1,2,4]三嗪作为用于治疗焦虑症的GABA(A)α2/3亚型选择性激动剂。

J Med Chem. 2006 Feb 23;49(4):1235-8. doi: 10.1021/jm051200u.

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7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.7-(1,1-二甲基乙基)-6-(2-乙基-2H-1,2,4-三唑-3-基甲氧基)-3-(2-氟苯基)-1,2,4-三唑并[4,3-b]哒嗪：一种功能选择性γ-氨基丁酸(A)(GABA(A))α2/α3亚型选择性激动剂，在动物模型中表现出强效抗焦虑活性但无镇静作用。

J Med Chem. 2005 Nov 17;48(23):7089-92. doi: 10.1021/jm058034a.

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Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.哌嗪咪唑并[1,5 - a]喹喔啉脲作为具有双重功能的高亲和力GABAA配体。

J Med Chem. 1999 Apr 8;42(7):1123-44. doi: 10.1021/jm9801307.

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SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.SL651498：一种对含α2和α3的γ-氨基丁酸A（GABA(A)）受体具有功能选择性的抗焦虑化合物。

J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.

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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.3-苯基-6-(2-吡啶基)甲氧基-1,2,4-三唑并[3,4-a]酞嗪及其类似物：对α1具有α2、α3和α5亚型结合选择性的高亲和力γ-氨基丁酸-A苯二氮䓬受体配体

J Med Chem. 2004 Mar 25;47(7):1807-22. doi: 10.1021/jm031020p.

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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.TPA023 [7-(1,1-二甲基乙基)-6-(2-乙基-2H-1,2,4-三唑-3-基甲氧基)-3-(2-氟苯基)-1,2,4-三唑并[4,3-b]哒嗪]，一种对含α2和α3的GABAA受体具有选择性的激动剂，在啮齿动物和灵长类动物中是一种无镇静作用的抗焦虑药。

J Pharmacol Exp Ther. 2006 Jan;316(1):410-22. doi: 10.1124/jpet.105.089920. Epub 2005 Sep 23.

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咪唑并[1,2 - a]吡嗪 - 8 - 酮、咪唑并[1,2 - d][1,2,4]三嗪 - 8 - 酮和咪唑并[2,1 - f][1,2,4]三嗪 - 8 - 酮作为α2/α3亚型选择性GABA A激动剂用于治疗焦虑症。

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

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