Tian Haijun, Robinson Rebecca L, Sturm Roland
Pardee RAND Graduate School, Santa Monica, CA 90407-2138, USA.
J Ment Health Policy Econ. 2005 Dec;8(4):219-28.
The economic burden of depression has been documented, but the role of comorbid conditions is unclear. Depression and comorbid pain are particularly common, are associated with worse clinical outcomes and require different care than "pure'' depression. Does this comorbidity account for a large share of the adverse social outcomes attributed to depression?
We analyzed the relationship between depression and comorbid pain, and labor market, financial, insurance and disability outcomes among Americans aged 55-65.
Cross-sectional data were used from Wave 3 of the Health and Retirement Survey, a nationally representative sample of individuals aged 55-65 surveyed in 1996. Multivariate regression analyses, controlling for socio-demographics and chronic health conditions, estimated the associations between depression and pain, and economic outcomes. Outcomes included: employment and retirement status, household income, total medical expenditures, government health insurance, social security, limitations in activities of daily living (ADLs), and health limitations affecting work. Primary explanatory variables included the presence of severe pain, mild/moderate pain, or absence of pain, with or without depression.
Compared to depression alone, depression and comorbid pain was associated with worse labor market (non-employment, retirement), financial (total medical expenditures), insurance (government insurance, social security) and disability outcomes (limitations in ADLs, health limitations affecting work), after covariate adjustment (p <or= 0.01, except retirement with p < 0.1). Findings were even more disparate as level of pain severity increased. The simulated results showed that the magnitudes of the adverse effects were attributed disproportionally to individuals with comorbid pain and depression versus "pure'' depression. Of those with depression, 51% had comorbid pain. Yet, this subgroup of depressed individuals accounted for 59% of those not employed, 61% of those with government health insurance, 79% of those with limitations in ADLs, and 72% of those with health limitations affecting work. DISCUSSION AND LIMITATION: Depression with comorbid pain, not depression alone was responsible for a large part of the higher economic burden associated with depression. The study is limited by self-reported measures of pain, depression, and outcomes. It is cross-sectional and cannot identify causal effects of depression with pain. These findings may not be generalizable to other age groups.
The depressed with comorbid pain appear to experience greater burden through increased costs and worse functioning and may require different management than those with depression alone. The depressed with comorbid pain may benefit from treatment practices and guidelines that address the duality of these conditions throughout the process of care. IMPLICATION FOR HEALTH POLICIES: The depressed with comorbid pain were more likely to receive government support than depression alone. Given the central role of employer-sponsored health insurance in the U.S., they may have worse access to health care because they leave employment or retire earlier. With the evolving state of Medicare, broad formulary access to mental health treatments might be considered.
Further research should focus on causality of depression and comorbid pain on economic outcomes. Depression research should consider the heterogeneity of this disorder in outcomes assessment.
抑郁症的经济负担已有文献记载,但共病状况的作用尚不清楚。抑郁症与共病性疼痛尤为常见,与更差的临床结局相关,且需要不同于“单纯”抑郁症的护理。这种共病是否在归因于抑郁症的不良社会结局中占很大比例?
我们分析了55 - 65岁美国人中抑郁症与共病性疼痛之间的关系,以及劳动力市场、财务、保险和残疾状况。
使用健康与退休调查第3波的横断面数据,该数据是1996年对55 - 65岁人群进行的全国代表性样本。多变量回归分析在控制社会人口统计学和慢性健康状况的情况下,估计了抑郁症与疼痛以及经济结局之间的关联。结局包括:就业和退休状况、家庭收入、总医疗支出、政府医疗保险、社会保障、日常生活活动(ADL)受限情况以及影响工作的健康受限情况。主要解释变量包括是否存在重度疼痛、轻度/中度疼痛或无疼痛,伴有或不伴有抑郁症。
与单纯抑郁症相比,在进行协变量调整后,抑郁症与共病性疼痛与更差的劳动力市场(失业、退休)、财务(总医疗支出)、保险(政府保险、社会保障)和残疾状况(ADL受限、影响工作的健康受限)相关(p≤0.01,但退休情况p < 0.1)。随着疼痛严重程度的增加,结果差异更大。模拟结果表明,不良影响的程度不成比例地归因于共病性疼痛和抑郁症患者,而非“单纯”抑郁症患者。在患有抑郁症的人群中,51%患有共病性疼痛。然而,这一抑郁症亚组占失业者的59%、拥有政府医疗保险者的61%、ADL受限者的79%以及影响工作的健康受限者的72%。
伴有共病性疼痛的抑郁症,而非单纯抑郁症,是与抑郁症相关的更高经济负担的很大一部分原因。该研究受疼痛、抑郁症及结局的自我报告测量方法的限制。它是横断面研究,无法确定抑郁症与疼痛的因果效应。这些发现可能不适用于其他年龄组。
伴有共病性疼痛的抑郁症患者似乎因成本增加和功能更差而承受更大负担,可能需要与单纯抑郁症患者不同的管理方式。伴有共病性疼痛的抑郁症患者可能会从在整个护理过程中处理这些状况双重性的治疗方法和指南中受益。
伴有共病性疼痛的抑郁症患者比单纯抑郁症患者更有可能获得政府支持。鉴于美国雇主赞助的医疗保险的核心作用,他们可能因更早离职或退休而获得医疗保健的机会更差。随着医疗保险状况的演变,可考虑广泛提供心理健康治疗药物。
进一步的研究应关注抑郁症和共病性疼痛对经济结局的因果关系。抑郁症研究应在结局评估中考虑该疾病的异质性