Slavin Konstantin V, Nersesyan Hrachya, Wess Christian
Department of Neurosurgery, University of Illinois, Chicago, Illinois 60612, USA.
Neurosurgery. 2006 Jan;58(1):112-9; discussion 112-9. doi: 10.1227/01.neu.0000192163.55428.62.
Medically intractable pain caused by occipital neuralgia (ON) can be very difficult to control with traditional pain management. Peripheral nerve stimulation (PNS) may serve as a good alternative to destructive surgical manipulations used currently for the treatment of severe ON.
We analyzed records of 14 consecutive patients (9 women and 5 men; mean age, 43.3 yr) with intractable ON treated with PNS during the period from April 2002 to November 2004. Five patients had unilateral and nine had bilateral PNS electrodes inserted for trial, which was considered successful if patient reported at least 50% decrease of pain on the visual analogue scale. Ten patients proceeded with system internalization, and their long-term results were analyzed.
At the time of the last follow-up examination (5-32 mo, mean 22 mo), seven patients (70%) with implanted PNS systems continue to experience beneficial effects of stimulation, including adequate pain control, continuous employment, and decrease in oral pain medications intake. Two patients had their systems explanted because of loss of stimulation effect or significant improvement of pain, and one patient had part of his hardware removed because of infection.
Overall, the beneficial effect from chronic stimulation in our series persisted in more than half of the patients for whom procedure was considered and in 80% of those who significantly improved during the trial and proceeded with internalization. Thus, chronic PNS may be a safe and relatively effective method for long-term treatment of chronic pain syndrome in patients with medically intractable ON.
枕神经痛(ON)所致的药物难治性疼痛很难用传统的疼痛管理方法控制。外周神经刺激(PNS)可能是目前用于治疗重度ON的破坏性手术操作的良好替代方法。
我们分析了2002年4月至2004年11月期间14例接受PNS治疗的难治性ON患者(9例女性和5例男性;平均年龄43.3岁)的记录。5例患者进行单侧PNS电极植入试验,9例进行双侧PNS电极植入试验,若患者报告视觉模拟量表上疼痛至少减轻50%,则认为试验成功。10例患者进行了系统植入,并分析了其长期结果。
在最后一次随访检查时(5 - 32个月,平均22个月),7例(70%)植入PNS系统的患者继续体验到刺激的有益效果,包括疼痛得到充分控制、能够持续工作以及口服止痛药物摄入量减少。2例患者因刺激效果丧失或疼痛显著改善而取出系统,1例患者因感染取出部分硬件。
总体而言,在我们的系列研究中,对于考虑进行该手术的患者,超过半数患者以及在试验期间显著改善并进行了植入的患者中80%,慢性刺激的有益效果持续存在。因此,慢性PNS可能是长期治疗药物难治性ON患者慢性疼痛综合征的一种安全且相对有效的方法。