Valesini G
Dipartimento di Clinica e Terapia Medica Applicata, Cattedra di Reumatologia, Università degli Studi La Sapienza, Roma, Italia.
Reumatismo. 2005;57(4 Suppl):1-2. doi: 10.4081/reumatismo.2005.4s.1.
To provide an analysis and a guide tool in using TNFα-antagonists in the current clinical practice.
Review of the literature on the differences among the three TNFα-antagonists in terms of molecular structure, mechanism of action, pharmacokinetics, effects on the immune and neuroendocrine systems, and therapeutic indications.
Unfortunately, results of direct comparison studies are lacking. One could obviate this problem by performing statistical-mathematical extrapolations, but there are very few and very small-sized published experimental evidences.
为当前临床实践中使用肿瘤坏死因子α拮抗剂提供分析和指导工具。
回顾关于三种肿瘤坏死因子α拮抗剂在分子结构、作用机制、药代动力学、对免疫和神经内分泌系统的影响以及治疗适应症方面差异的文献。
遗憾的是，缺乏直接比较研究的结果。可以通过进行统计数学推断来避免这个问题，但已发表的实验证据非常少且规模很小。
