[Are there differences among anti-TNFα biological drugs?].

OBJECTIVE

To provide an analysis and a guide tool in using TNFα-antagonists in the current clinical practice.

METHODS

Review of the literature on the differences among the three TNFα-antagonists in terms of molecular structure, mechanism of action, pharmacokinetics, effects on the immune and neuroendocrine systems, and therapeutic indications.

RESULTS AND CONCLUSIONS

Unfortunately, results of direct comparison studies are lacking. One could obviate this problem by performing statistical-mathematical extrapolations, but there are very few and very small-sized published experimental evidences.