ML-236A和ML-236B真菌代谢产物对3-羟基-3-甲基戊二酰辅酶A还原酶的竞争性抑制作用，具有降胆固醇活性。 - Suppr

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.

作者信息

Endo A, Kuroda M, Tanzawa K

机构信息

Fermentation Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140, Japan.

出版信息

FEBS Lett. 1976 Dec 31;72(2):323-6. doi: 10.1016/0014-5793(76)80996-9.

DOI:10.1016/0014-5793(76)80996-9

PMID:16386050

Abstract

摘要

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.

作者信息

Endo A, Kuroda M, Tanzawa K

机构信息

Fermentation Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140, Japan.

出版信息

FEBS Lett. 1976 Dec 31;72(2):323-6. doi: 10.1016/0014-5793(76)80996-9.

DOI:10.1016/0014-5793(76)80996-9

PMID:16386050

Abstract

摘要