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Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

作者信息

Endo A

出版信息

J Antibiot (Tokyo). 1980 Mar;33(3):334-6. doi: 10.7164/antibiotics.33.334.

DOI:10.7164/antibiotics.33.334
PMID:7380744
Abstract
摘要

相似文献

1
Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.莫纳可林K，一种新型降胆固醇药物，它能特异性抑制3-羟基-3-甲基戊二酰辅酶A还原酶。
J Antibiot (Tokyo). 1980 Mar;33(3):334-6. doi: 10.7164/antibiotics.33.334.
2
Mevinolin: a highly specific inhibitor of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase of radish plants.美维诺林：萝卜植物微粒体3-羟基-3-甲基戊二酰辅酶A还原酶的一种高度特异性抑制剂。
Z Naturforsch C Biosci. 1982 Jan-Feb;37(1-2):46-50. doi: 10.1515/znc-1982-1-209.
3
Monacolin M, a new inhibitor of cholesterol biosynthesis.莫纳可林M，一种新的胆固醇生物合成抑制剂。
J Antibiot (Tokyo). 1986 Dec;39(12):1670-3. doi: 10.7164/antibiotics.39.1670.
4
3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors.3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂
Methods Enzymol. 1981;72:684-9. doi: 10.1016/s0076-6879(81)72058-5.
5
Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B.
Biochem Biophys Res Commun. 1978 May 15;82(1):247-54. doi: 10.1016/0006-291x(78)90602-2.
6
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.普伐他汀钠（一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）对体内胆固醇合成的组织选择性抑制作用。
Biochim Biophys Acta. 1990 Jul 16;1045(2):115-20. doi: 10.1016/0005-2760(90)90139-o.
7
Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.ML-236A和ML-236B真菌代谢产物对3-羟基-3-甲基戊二酰辅酶A还原酶的竞争性抑制作用，具有降胆固醇活性。
FEBS Lett. 1976 Dec 31;72(2):323-6. doi: 10.1016/0014-5793(76)80996-9.
8
Inhibition of rat brain prostaglandin D synthase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂对大鼠脑前列腺素D合酶的抑制作用
Biochem Int. 1990 Nov;22(4):601-5.
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Microbial hydroxylation of compactin (ML-236B) and monacolin K.
J Antibiot (Tokyo). 1985 May;38(5):605-9. doi: 10.7164/antibiotics.38.605.
10
Hypocholesterolemic agents VII: Inhibition of beta-hydroxy-beta-methylglutaryl-CoA reductase by monoesters of substituted glutaric acids.
J Pharm Sci. 1980 May;69(5):506-9. doi: 10.1002/jps.2600690507.

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