新型哌嗪基恶唑烷酮的4-N-取代芳基戊-2-烯-1,4-二酮衍生物作为抗菌剂
Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials.
作者信息
Lohray Braj Bhushan, Lohray Vidya Bhushan, Srivastava Brijesh Kumar, Gupta Sunil, Solanki Manish, Pandya Purvi, Kapadnis Prashant
机构信息
Zydus Research Centre, Sarkhej-Bavla N.H 8A Moraiya, Ahmedabad-382210, India.
出版信息
Bioorg Med Chem Lett. 2006 Mar 15;16(6):1557-61. doi: 10.1016/j.bmcl.2005.12.025. Epub 2005 Dec 28.
A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid.
已经合成了几种在哌嗪环骨架的远端氮原子上有取代基的取代哌嗪基苯基恶唑烷酮化合物6-13，并对它们在革兰氏阳性菌中的抗菌活性进行了评估。一些化合物对金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌和化脓性链球菌显示出比利奈唑胺和依哌唑胺更强的体外抗菌活性。
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