新型恶唑烷酮类曼尼希酮作为抗菌剂

Novel Mannich ketones of oxazolidinones as antibacterial agents.

作者信息

Srivastava Brijesh Kumar, Kapadnis Prashant B, Pandya Purvi, Lohray Vidya Bhushan

机构信息

Zydus Research Centre, Sarkhej- Bavla N. H.8A, Moraiya, Ahmedabad 382210, India.

出版信息

Eur J Med Chem. 2004 Nov;39(11):989-92. doi: 10.1016/j.ejmech.2004.07.007.

DOI:10.1016/j.ejmech.2004.07.007

PMID:15501548

Abstract

A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compound 12 showed comparable activity (MIC) to linezolid and superior to eperezolid.

摘要

已经合成了几种哌嗪基恶唑烷酮衍生物的曼尼希酮，并通过测定最低抑菌浓度（MIC）评估了它们对各种革兰氏阳性菌的抗菌活性，这些革兰氏阳性菌包括枯草芽孢杆菌、金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌。化合物12显示出与利奈唑胺相当的活性（MIC），且优于依哌唑胺。