Hardin Christopher D, Vallejo Johana
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
Cardiovasc Res. 2006 Mar 1;69(4):808-15. doi: 10.1016/j.cardiores.2005.11.024. Epub 2006 Jan 4.
Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.
小窝越来越被认为是血管平滑肌(VSM)中各种信号和能量转导系统的重要组织结构。在本综述中,我们讨论了小窝蛋白在组织和调节平滑肌基本功能方面的新作用:收缩、生长/增殖以及支持这些功能的能量支持系统。随着VSM中细胞代谢和功能因小窝蛋白-1(Cav-1)蛋白表达改变而出现明显变化,以及与Cav-1基因敲除小鼠相关的心血管异常,小窝蛋白家族可能在VSM的功能和功能障碍中发挥重要作用。