载脂蛋白A5变体Ser19Trp在一项针对男性的8年队列研究中影响总胆固醇水平的降低。

APOA5 variant Ser19Trp influences a decrease of the total cholesterol in a male 8 year cohort.

作者信息

Hubacek J A, Skodová Z, Adámková V, Lánská V, Pitha J

机构信息

Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

出版信息

Clin Biochem. 2006 Feb;39(2):133-6. doi: 10.1016/j.clinbiochem.2005.11.012. Epub 2005 Dec 28.

DOI:10.1016/j.clinbiochem.2005.11.012

PMID:16386723

Abstract

OBJECTIVES

To evaluate whether the relationship between dietary composition and plasma lipid levels is genetically determined.

DESIGN AND METHODS

We have evaluated the influence of common apolipoprotein A5 (APOA5) variants (T-1131 > C, Ser19 > Trp and Val153 > Met) on plasma lipid concentrations in 117 males for whom dietary composition markedly changed and total cholesterol decreased (from 6.21 +/- 1.31 mmol/L in 1988 to 5.43 +/- 1.06 mmol/L in 1996) over an 8 year follow-up study.

RESULTS

APOA5 T-1131 > C and Val153 > Met variants did not influence the change in lipid measures over time. In Ser/Ser19 homozygotes, the plasma cholesterol was relatively stable over the years (6.1 +/- 1.2 mmol/L in 1988 and 5.6 +/- 1.0 mmol/L in 1996, -8%, P < 0.01). In contrast, in the Trp19 carriers, the decrease of the plasma cholesterol was more than 20% (6.5 +/- 1.6 mmol/L in 1988 and 5.1 +/- 1.0 mmol/L in 1996) (P < 0.001). The difference of the changes is significant (8% vs. 20%, P < 0.005). Changes in other analyzed lipid parameters have not been significantly associated with APOA5 variants.

CONCLUSIONS

Ser19 > Trp variant in the APOA5 gene may play an important role in an individual's sensitivity to dietary composition.

摘要

目的

评估饮食成分与血浆脂质水平之间的关系是否由基因决定。

设计与方法

我们评估了常见载脂蛋白A5（APOA5）变体（T-1131>C、Ser19>Trp和Val153>Met）对117名男性血浆脂质浓度的影响，这些男性的饮食成分在8年的随访研究中发生了显著变化，总胆固醇降低（从1988年的6.21±1.31 mmol/L降至1996年的5.43±1.06 mmol/L）。

结果

APOA5 T-1131>C和Val153>Met变体不影响脂质指标随时间的变化。在Ser/Ser19纯合子中，多年来血浆胆固醇相对稳定（1988年为6.1±1.2 mmol/L，1996年为5.6±1.0 mmol/L，-8%，P<0.01）。相比之下，在Trp19携带者中，血浆胆固醇的降低超过20%（1988年为6.5±1.6 mmol/L，1996年为5.1±1.0 mmol/L）（P<0.001）。变化的差异具有显著性（8%对20%，P<0.005）。其他分析的脂质参数变化与APOA5变体无显著关联。