吸烟会影响人类喉部的免疫结构。
Smoking influences the immunological architecture of the human larynx.
作者信息
Rees Louisa E N, Jones Philip H, Ayoub Omar, Gunasekaran Sinnappa, Rajkumar Krishnan, Stokes Christopher R, Haverson Karin, Bailey Mick, Birchall Martin A
机构信息
Laryngeal Research Group, Division of Veterinary Pathology, Infection and Immunity, Clinical Veterinary Science, Langford House, Langford, Bristol BS40 5DU, UK.
出版信息
Clin Immunol. 2006 Feb-Mar;118(2-3):342-7. doi: 10.1016/j.clim.2005.10.015. Epub 2005 Dec 28.
Little is known about the effects of demographic and lifestyle factors on laryngeal mucosal immunology. Pinch biopsies of laryngeal mucosa were studied from 63 patients without laryngeal disease. Areas of positive staining for HLA-DR, HLA-DQ, HLA-DP, CD45, CD45RA, CD45RO, CD4, CD8, and CD79 were calculated. Patients were stratified according to gender and smoking status. Analysis of covariance showed current cigarette smokers had increased numbers of CD4+ T cells and there was an association between older age and greater CD4+ T cell numbers in both epithelium and lamina propria. Older age and female gender were associated with decreased lamina propria CD4+ CD45RO+ T cells and an increase in CD4+ CD45RO- T cells. T cell populations in the larynx may therefore be influenced by smoking, age and gender. We hypothesize that smoking induces changes in normal immunological function of the larynx, which may contribute to the etiology of inflammatory disease and cancer.
关于人口统计学和生活方式因素对喉黏膜免疫学的影响，目前所知甚少。对63例无喉部疾病患者的喉黏膜进行钳取活检研究。计算HLA - DR、HLA - DQ、HLA - DP、CD45、CD45RA、CD45RO、CD4、CD8和CD79的阳性染色面积。患者根据性别和吸烟状况进行分层。协方差分析显示，当前吸烟者的CD4⁺T细胞数量增加，并且在年龄较大者的上皮和固有层中，CD4⁺T细胞数量较多。年龄较大和女性与固有层CD4⁺CD45RO⁺T细胞减少及CD4⁺CD45RO⁻T细胞增加有关。因此，喉部的T细胞群体可能受吸烟、年龄和性别的影响。我们推测，吸烟会引起喉部正常免疫功能的改变，这可能有助于炎症性疾病和癌症的病因学研究。
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