Boengler K, Schulz R, Heusch G
Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany.
Heart. 2006 Dec;92(12):1724-7. doi: 10.1136/hrt.2005.066878. Epub 2005 Dec 30.
Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial Cx43 in protection by IP is reviewed.
连接蛋白(Cx)43是在心室心肌中形成间隙连接和非连接半通道的主要蛋白质。Cx43蛋白对于缺血预处理(IP)所提供的心脏保护作用至关重要。本文综述了线粒体Cx43在IP保护中的具体作用。