Rajkumar L, Balasubramanian K, Arunakaran J, Govindarajulu P, Srinivasan N
Department of Pathology, Texas Tech University Health Science Center, 4800 Alberta Avenue, El Paso, 79905, USA.
Cell Biol Int. 2006 Feb;30(2):164-8. doi: 10.1016/j.cellbi.2005.10.018. Epub 2006 Jan 4.
Estradiol plays a vital role in the growth and development of mammary glands. It is a potent stimulator of metabolic processes in normal and carcinoma breast. A critical factor in determining mammary glandular morphology is the stroma. Collagen is a predominant component of the extracellular matrix and cell-collagen interactions are essential carcinogenesis. The present investigation explored the influence of estradiol on collagen solubility and metabolism in mammary tumors during tumor progression and regression. A single injection of 20 mg of 9,10-dimethyl-1,2-benzanthracene was given to rats at 7 weeks of age. With the appearance of the first palpable mammary tumor, the rats were treated with 0.5 microg estradiol or 50 microg tamoxifen daily for 30 days. The rats were sacrificed 24 h after 30 days of treatment. Estradiol appears to stimulate the synthesis of new collagens and thus contributes to the enlargement of the mammary tumors. This might have created a potential microenvironment by increasing the synthesis of suitable matrix that sustains the growth of the mammary tumors. In short, the present findings emphasize a definite mediatory role for collagen in estradiol promoted mammary tumor growth.
雌二醇在乳腺的生长和发育中起着至关重要的作用。它是正常乳腺和乳腺癌中代谢过程的有力刺激物。决定乳腺形态的一个关键因素是间质。胶原蛋白是细胞外基质的主要成分，细胞与胶原蛋白的相互作用是致癌作用的关键。本研究探讨了雌二醇在肿瘤进展和消退过程中对乳腺肿瘤中胶原蛋白溶解性和代谢的影响。在7周龄的大鼠中单次注射20mg的9,10 - 二甲基 - 1,2 - 苯并蒽。当首次触及乳腺肿瘤时，大鼠每天接受0.5μg雌二醇或50μg他莫昔芬治疗30天。治疗30天后24小时处死大鼠。雌二醇似乎刺激了新胶原蛋白的合成，从而促进了乳腺肿瘤的增大。这可能通过增加维持乳腺肿瘤生长的合适基质的合成而创造了一个潜在的微环境。简而言之，本研究结果强调了胶原蛋白在雌二醇促进乳腺肿瘤生长中具有明确的介导作用。
