Milhorat T H, Davis D A, Hammock M K
J Neurosurg. 1975 Mar;42(3):315-29. doi: 10.3171/jns.1975.42.3.0315.
The authors demonstrate that, while the intracerebral movement of proteins and other relatively large molecules is restricted by tight junctions of endothelia and epithelia of the brain, calcium ion penetrates these barriers and moves between the blood and CSF cavities by extracellular pathways. Mechanisms underlying CSF formation are considered on the basis of this anatomical continuity of the vascular, extracellular, and CSF compartments of the brain for very small molecules.
作者们证明，虽然蛋白质和其他相对大分子在脑内的移动受到脑内皮细胞和上皮细胞紧密连接的限制，但钙离子可穿透这些屏障，并通过细胞外途径在血液和脑脊液腔之间移动。基于脑的血管、细胞外和脑脊液腔室对于非常小分子的这种解剖学连续性，对脑脊液形成的潜在机制进行了探讨。
