Zhang Ming, Alicot Elisabeth M, Chiu Isaac, Li Jinan, Verna Nicola, Vorup-Jensen Thomas, Kessler Benedikt, Shimaoka Motomu, Chan Rodney, Friend Daniel, Mahmood Umar, Weissleder Ralph, Moore Francis D, Carroll Michael C
CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
J Exp Med. 2006 Jan 23;203(1):141-52. doi: 10.1084/jem.20050390. Epub 2006 Jan 3.
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
再灌注损伤（RI）是一种潜在的危及生命的疾病，是心肌梗死、中风、手术或创伤导致的缺血期后的急性炎症反应。最近发现一种引发RI的单克隆天然IgM，从而确定非肌肉肌球蛋白重链II A型和C型为两种不同组织中的自身靶点。这些结果确定了一条新途径，即对缺氧应激导致的高度保守自身抗原的先天反应会导致组织破坏。
