Amendt P, Hesse V, Rohde W
Childrens Hospital, Berlin/Germany.
Exp Clin Endocrinol. 1992;99(2):73-6. doi: 10.1055/s-0029-1211138.
To clarify the pathogenesis of growth retardation in patients with Ullrich-Turner's syndrome (TS) we have investigated basal SmC/IGF-I, insulin and prolactin concentrations. Compared with 56 age matched healthy controls basal SmC/IGF-I concentration in 51 patients with TS older than 9-11 years was significantly lower (age group 13-14 years; TS 273 +/- 47 and controls 479 +/- 114 ng/ml). Mean basal prolactin level in 43 patients with TS (406 +/- 211 microU/ml) was significantly higher (p less than 0.01) than in 192 female controls (age 3-11 years; 264 +/- 176 microU/ml). Basal insulin concentration in 28 TS patients in comparison to 20 healthy children of a control group was significant higher (TS 18 +/- 8 microU/ml; controls 9 +/- 4 microU/ml; p less than 0.01). It seems that neither insulin nor prolactin are relevant stimulators of Smc/IGF-I in man, especially in patients with gonadal dysgenesis. Considering these results we speculate that despite higher prolactin and higher insulin levels in TS, the lower SmC/IGF-I concentrations may be predominantly related to the abnormal sex steroid secretion.
为了阐明乌尔里希 - 特纳综合征（TS）患者生长发育迟缓的发病机制，我们研究了基础状态下的硫酸软骨素/胰岛素样生长因子 - I（SmC/IGF - I）、胰岛素和催乳素浓度。与56名年龄匹配的健康对照者相比，51例年龄大于9 - 11岁的TS患者基础状态下的SmC/IGF - I浓度显著降低（年龄组13 - 14岁；TS组为273±47 ng/ml，对照组为479±114 ng/ml）。43例TS患者的基础催乳素平均水平（406±211 μU/ml）显著高于192名女性对照者（年龄3 - 11岁；264±176 μU/ml；p<0.01）。与20名对照组健康儿童相比，28例TS患者的基础胰岛素浓度显著更高（TS组为18±8 μU/ml；对照组为9±4 μU/ml；p<0.01）。似乎胰岛素和催乳素都不是人类尤其是性腺发育不全患者中Smc/IGF - I的相关刺激因子。考虑到这些结果，我们推测尽管TS患者中催乳素和胰岛素水平较高，但较低的SmC/IGF - I浓度可能主要与异常的性类固醇分泌有关。
