Khanna Vikrant, Alam Seema, Malik Ashraf, Malik Abida
Department of Pediatrics, JN Medical College, Aligarh Muslim University, Aligarh, India.
Indian J Pediatr. 2005 Nov;72(11):935-8. doi: 10.1007/BF02731667.
A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea.
All children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 the placebo.
ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance.
There is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.
开展一项双盲随机对照试验，以评估灭活嗜酸乳杆菌对急性腹泻的疗效。
纳入所有6个月至12岁的急性腹泻儿童。给予儿童嗜酸乳杆菌/安慰剂，同时搭配口服补液盐（ORS）并进行喂养，为期3天。每4小时记录摄入量和排出量。98名儿童中，48名接受了嗜酸乳杆菌治疗，50名接受了安慰剂治疗。
两个研究组在口服补液盐的消耗量、排便频率、腹泻持续时间、补液时间、住院时间、体重增加以及所需静脉输液量方面具有可比性。嗜酸乳杆菌组有4例治疗失败，安慰剂组无治疗失败病例（比值比0.92，95%置信区间0.84 - 0.99）。在轮状病毒性腹泻以及腹泻时间少于60小时的患者中，差异未达到统计学显著性。
灭活嗜酸乳杆菌对急性腹泻无显著益处。
Zotero 插件