缺氧诱导因子羟化酶为缺氧信号传导带来了新的契机。
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.
作者信息
Berra Edurne, Ginouvès Amandine, Pouysségur Jacques
机构信息
Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne, France.
出版信息
EMBO Rep. 2006 Jan;7(1):41-5. doi: 10.1038/sj.embor.7400598.
Abstract
Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, 'senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF-alpha subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.
摘要
后生动物通过调节基因表达对氧可利用性的变化做出快速反应。转录因子缺氧诱导因子（HIF）控制多个基因的表达，它通过两个脯氨酸残基的羟基化间接“感知”氧浓度，而这种羟基化会标记HIF-α亚基以便进行蛋白酶体降解。我们综述了HIF脯氨酰羟化酶或脯氨酰羟化酶结构域蛋白的表达、调控及功能，它们是真正的氧传感器。
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