Kaelin William G
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cell Metab. 2005 Jun;1(6):357-8. doi: 10.1016/j.cmet.2005.05.006.
The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
活性氧（ROS）在细胞对细胞氧感应的反应中的作用一直存在争议。本期《细胞代谢》杂志上的三篇论文（布鲁内尔等人、古齐等人，2005年；曼斯菲尔德等人，2005年）使用基因工具证实，线粒体产生的ROS是低氧正常诱导缺氧诱导因子（HIF，一种氧敏感基因表达的主要调节因子）所必需的。
