β-芳基硝基乙烯与其他活性烯烃的森田-贝利斯-希尔曼加合物：合成与抗癌活性研究
The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies.
作者信息
Dadwal Mamta, Mohan Renu, Panda Dulal, Mobin Shaikh M, Namboothiri Irishi N N
机构信息
Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
出版信息
Chem Commun (Camb). 2006 Jan 21(3):338-40. doi: 10.1039/b512267h. Epub 2005 Nov 21.
DOI:10.1039/b512267h
PMID:16391753
Abstract
The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell proliferation by binding to tubulin.
摘要
在室温下，β-芳基硝基乙烯与甲基乙烯基酮（MVK）和丙烯酸酯的森田-贝利斯-希尔曼（MBH）加合物在四氢呋喃中由咪唑/氯化锂介导时，以中等至良好的产率形成，通过与微管蛋白结合抑制HeLa细胞增殖。
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