α-氨基烷基化共轭硝基烯烃的合成与抗癌活性研究
Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes.
作者信息
Rastogi Namrata, Mohan Renu, Panda Dulal, Mobin Shaikh M, Namboothiri Irishi N N
机构信息
Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
出版信息
Org Biomol Chem. 2006 Sep 7;4(17):3211-4. doi: 10.1039/b607537a. Epub 2006 Jul 28.
DOI:10.1039/b607537a
PMID:17036105
Abstract
Novel alpha-aminoalkylated conjugated nitroalkenes which inhibit human cervical cancer (HeLa) cell proliferation by binding to tubulin were synthesized by imidazole/LiCl-mediated reaction of conjugated nitroalkenes with N-tosylimines.
摘要
通过共轭硝基烯烃与N-甲苯磺酰亚胺的咪唑/氯化锂介导反应合成了新型α-氨基烷基化共轭硝基烯烃，该化合物通过与微管蛋白结合来抑制人宫颈癌（HeLa）细胞增殖。
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