Oldak Monika, Smola-Hess Sigrun, Maksym Radoslaw
Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, PL-02004 Warsaw, Poland.
Int J Mol Med. 2006 Feb;17(2):195-202.
Integrin beta4 is a transmembrane protein expressed predominantly on epithelial cells. In human epidermis integrin beta4 associates with integrin beta6. Integrin alpha6beta4 is concentrated at the basement membrane zone, where it localizes to specialized adhesion structures called hemidesmosomes. In addition to its adhesive functions, keratinocyte integrin beta4 has been identified as an important regulator of epidermal homeostasis. This review summarizes the current knowledge regarding the role of integrin beta4 in keratinocyte adhesion, migration, as well as growth and differentiation. Changes in integrin beta4 expression in pathological conditions in skin and mucosa, especially those associated with human papillomavirus infection, are described.
整合素β4是一种主要在上皮细胞表达的跨膜蛋白。在人类表皮中，整合素β4与整合素β6相关联。整合素α6β4集中于基底膜区，定位于称为半桥粒的特殊黏附结构。除了其黏附功能外，角质形成细胞整合素β4已被确定为表皮稳态的重要调节因子。本综述总结了关于整合素β4在角质形成细胞黏附、迁移以及生长和分化中作用的当前知识。描述了皮肤和黏膜病理状况下，尤其是与人乳头瘤病毒感染相关的状况下整合素β4表达的变化。
