丙型肝炎相关的难治性糜烂性口腔扁平苔藓：局部应用他克莫司软膏的疗效
Refractory erosive oral lichen planus associated with hepatitis C: response to topical tacrolimus ointment.
作者信息
Donovan Jeffrey C H, Hayes Robert C, Burgess Karen, Leong Iona T, Rosen Cheryl F
机构信息
Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Cutan Med Surg. 2005 Apr;9(2):43-6. doi: 10.1007/s10227-005-0038-y.
BACKGROUND
Erosive lichen planus is a painful and disabling disease that is frequently resistant to topical and systemic therapies. Current therapies are considered palliative rather than curative as many patients relapse after discontinuing treatment. An association has been reported between some cases of oral lichen planus (OLP) and chronic hepatitis C infection.
OBJECTIVE
We report on a 51-year-old hepatitis C-positive man with corticosteroid refractory erosive lichen planus of the lip who had a rapid resolution of his lesions following a two-week course of topical 0.1% tacrolimus ointment. The patient remains symptom-free at one year post-treatment.
CONCLUSION
This case supports the safety and efficacy of topical tacrolimus in patients with steroid-refractory OLP associated with chronic hepatitis C.
背景
糜烂性扁平苔藓是一种疼痛且致残的疾病，通常对局部和全身治疗均有抵抗性。当前的治疗方法被认为只是姑息性的而非治愈性的，因为许多患者在停止治疗后会复发。有报道称某些口腔扁平苔藓（OLP）病例与慢性丙型肝炎感染之间存在关联。
目的
我们报告了一名51岁的丙型肝炎阳性男性，患有唇部皮质类固醇难治性糜烂性扁平苔藓，在接受为期两周的局部0.1%他克莫司软膏治疗后，其病损迅速消退。患者在治疗后一年仍无症状。
结论
该病例支持局部使用他克莫司治疗与慢性丙型肝炎相关的类固醇难治性OLP的安全性和有效性。
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