Tavassol F, Starke O F, Völker B, Kokemüller H, Eckardt A
Department of Oral and Maxillofacial Surgery, Hanover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.
Int J Oral Maxillofac Surg. 2008 Jan;37(1):66-9. doi: 10.1016/j.ijom.2007.06.016. Epub 2007 Sep 5.
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknown etiology. Usually asymptomatic, the disorder is occasionally complicated by extensive painful erosions. Topical corticosteroids are the mainstay of treatment, but a new topical therapy with tacrolimus has been described previously. The aim of the current study was to examine the expression of heat-shock protein 70 (HSP70) in biopsy specimens from 11 OLP lesions before and after topical treatment with tacrolimus. Immunostaining was performed with anti-HSP70 antibody as the primary layer. Clinically, there was a rapid improvement with topical tacrolimus treatment in 10 out of the 11 patients. The moderate increase in HSP70 expression after treatment with tacrolimus was not significant. It was concluded that topical tacrolimus has no effect on the expression of HSP70 in OLP.
口腔扁平苔藓（OLP）是一种病因不明的慢性炎症性黏膜疾病。该疾病通常无症状，偶尔会并发广泛的疼痛性糜烂。局部用皮质类固醇是主要的治疗方法，但之前已描述了一种新的他克莫司局部治疗方法。本研究的目的是检测11例OLP病变活检标本在他克莫司局部治疗前后热休克蛋白70（HSP70）的表达。以抗HSP70抗体作为一抗进行免疫染色。临床上，11例患者中有10例经他克莫司局部治疗后迅速改善。他克莫司治疗后HSP70表达的适度增加并不显著。得出的结论是，他克莫司局部治疗对OLP中HSP70的表达没有影响。
