可待因耐受大鼠的脑和肾上腺单胺及神经肽Y

Brain and adrenal monoamines and neuropeptide Y in codeine tolerant rats.

Pages N, Orosco M, Rouch C, Fournier G, Comoy E, Bohuon C

Laboratoire de Toxicologie, Faculté de Pharmacie, Châtenay-Malabry, France.

Gen Pharmacol. 1992 Mar;23(2):159-63. doi: 10.1016/0306-3623(92)90003-3.

Abstract

Monoamine turnover and neuropeptide Y (NPY) levels were investigated in the central and peripheral nervous systems in adult male rats chronically treated with codeine. 2. An increase in the dopaminergic turnover was observed in the striatum and cortex. The norepinephrine levels and the serotoninergic turnover were unchanged in all the brain areas. 3. Epinephrine levels were decreased in the adrenal glands. 4. In addition, we observed a significant decrease of NPY levels in the hypothalamus, the striatum and the adrenal glands. These observed changes were not found when assessing NPY level in plasma fluid. 5. The implication of these modifications in the induction of codeine dependence are discussed in view of previous results obtained with morphine.

摘要

对长期用可待因治疗的成年雄性大鼠的中枢和外周神经系统中的单胺周转及神经肽Y（NPY）水平进行了研究。2. 在纹状体和皮质中观察到多巴胺能周转增加。所有脑区的去甲肾上腺素水平和5-羟色胺能周转均未改变。3. 肾上腺中的肾上腺素水平降低。4. 此外，我们观察到下丘脑、纹状体和肾上腺中的NPY水平显著降低。在评估血浆中的NPY水平时未发现这些观察到的变化。5. 鉴于先前用吗啡获得的结果，讨论了这些改变在可待因依赖性诱导中的意义。