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单次脉冲染料激光治疗新鲜手术瘢痕的临床效果:随机对照试验

Clinical effect of a single pulsed dye laser treatment of fresh surgical scars: randomized controlled trial.

作者信息

Alam Murad, Pon Kucy, Van Laborde S, Kaminer Michael S, Arndt Kenneth A, Dover Jeffrey S

机构信息

Section of Cutaneous and Aesthetic Surgery, Dept. of Dermatology, Northwestern University, Chicago, IL, USA.

出版信息

Dermatol Surg. 2006 Jan;32(1):21-5. doi: 10.1111/1524-4725.2006.32029.

Abstract

BACKGROUND

Pulsed dye laser has been used to decrease erythema and telangiectasia associated with scars, including surgical scars. There is limited evidence indicating improved surgical scar appearance if pulsed dye laser treatments are commenced immediately at the time of suture removal.

OBJECTIVE

To determine whether a single one-pass pulsed dye laser treatment at the time of suture removal can improve the appearance of surgical scars.

METHODS

Randomized controlled trial enrolling 20 patients (complete data for 17 patients) at two geographic sites, with blinded ratings of pre- and post-treatment photographs obtained at various time points. Included patients underwent elliptical excision for atypical nevi of the trunk and/or extremities, with at least one resulting scar of at least 5 cm in length or two scars of at least 2.5 cm in length. For each patient, each scar or half-scar (if a larger scar was used) was randomized to treatment or control groups. Treatment scars received a single one-pass treatment with a 595 nm pulsed dye laser (Vbeam, Candela Corporation, Wayland, MA, USA) at the time of suture removal (ie, 2 weeks after excision) at the following parameters: 7 J/cm2 fluence, 7 mm spot size, 1.5-millisecond pulse duration, and 30-millisecond spray, 20-millisecond delay of dynamic cooling. The treatment area included 1 cm on either side of the scar, and the round laser spots were overlapped 10%. Control scars were not treated with laser.

RESULTS

Immediate purpura was induced from the laser treatment Six weeks after laser treatment, no significant difference was found in the clinical appearance of surgical scars treated with a single pulsed dye laser treatment on suture removal day versus those surgical scars not treated with laser. Parameters on which no significant difference was found included visibility of incision, erythema, hyperpigmentation, hypopigmentation, induration, and atrophy. Both sets of scars improved over time.

CONCLUSIONS

A single pulsed dye laser treatment at the time of suture removal does not appear to have a beneficial effect on clinical scar appearance. The point of minimal benefit for such laser treatments may lie somewhere between one and three treatments.

摘要

背景

脉冲染料激光已被用于减轻与瘢痕(包括手术瘢痕)相关的红斑和毛细血管扩张。仅有有限的证据表明,如果在拆线时立即开始脉冲染料激光治疗,手术瘢痕外观会得到改善。

目的

确定在拆线时单次单脉冲染料激光治疗是否能改善手术瘢痕的外观。

方法

在两个地点进行的随机对照试验,纳入20例患者(17例患者有完整数据),在不同时间点对治疗前和治疗后的照片进行盲法评分。纳入的患者因躯干和/或四肢的非典型痣接受椭圆形切除术,至少形成一条长度至少为5 cm的瘢痕或两条长度至少为2.5 cm的瘢痕。对于每位患者,每个瘢痕或半条瘢痕(如果使用较大的瘢痕)被随机分配到治疗组或对照组。治疗瘢痕在拆线时(即切除术后2周)接受一次595 nm脉冲染料激光(Vbeam,美国马萨诸塞州韦兰市坎德拉公司)单脉冲治疗,参数如下:能量密度7 J/cm²、光斑大小7 mm、脉冲持续时间1.5毫秒、喷雾30毫秒、动态冷却延迟20毫秒。治疗区域包括瘢痕两侧各1 cm,圆形激光光斑重叠10%。对照瘢痕不进行激光治疗。

结果

激光治疗引起即刻紫癜。激光治疗6周后,在拆线日接受单次脉冲染料激光治疗的手术瘢痕与未接受激光治疗的手术瘢痕在临床外观上未发现显著差异。未发现显著差异的参数包括切口可见度、红斑、色素沉着、色素减退、硬结和萎缩。两组瘢痕随时间均有改善。

结论

拆线时单次脉冲染料激光治疗似乎对临床瘢痕外观没有有益影响。这种激光治疗的最小获益点可能在一至三次治疗之间的某个时间。

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