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多孔弹性心肌组织中稳定流的灌注研究。

Perfusion studies of steady flow in poroelastic myocardium tissue.

作者信息

Ng E Y K, Ghista D N, Jegathese R C

机构信息

Nanyang Technological University, School of Mechanical and Aerospace Engineering, Singapore, 639798, Singapore.

出版信息

Comput Methods Biomech Biomed Engin. 2005 Dec;8(6):349-57. doi: 10.1080/10420150500433044.

Abstract

The behaviour of the heart has always elicited interest and particularly the study of its myocardium, as 5-10% of the blood pumped by the heart is passed through the coronary arteries to the myocardium itself. An in-depth investigation of the myocardium behaviour is useful. The present work aims to investigate how myocardium perfusion is influenced by myocardial stress and diseased states, and in general by LV pumping abnormalities. LV myocardial perfusion can then serve as a possible index of the capacity of the LV to respond to its work demand, and thus of the risk of heart failure. The poroelastic analysis of the myocardium based on finite element method (FEM) for regional perfusion through a rectangular element with various physiological ranges of loading conditions was studied.

摘要

心脏的行为一直引发人们的兴趣,尤其是对其心肌的研究,因为心脏泵出的血液中有5-10%通过冠状动脉流向心肌本身。对心肌行为进行深入研究是有益的。目前的工作旨在研究心肌灌注如何受到心肌应激和疾病状态的影响,以及一般情况下如何受到左心室泵血异常的影响。左心室心肌灌注随后可作为左心室应对其工作需求能力的一个可能指标,从而作为心力衰竭风险的指标。研究了基于有限元法(FEM)对心肌进行多孔弹性分析,以通过具有各种生理负荷条件范围的矩形单元进行区域灌注。

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