Oxford Centre for Industrial and Applied mathematics, Mathematical Institute, 24-29 St Giles', Oxford, OX1 3LB, UK.
Prog Biophys Mol Biol. 2011 Jan;104(1-3):49-76. doi: 10.1016/j.pbiomolbio.2010.10.001. Epub 2010 Oct 30.
A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.
心脏生理系统项目的一个主要目标是开发理论模型，以模拟心脏在生理和病理生理条件下的功能行为。心脏功能的关键取决于通过冠状动脉血管系统向心肌输送足够的血液供应。冠状动脉血管系统的这一关键功能的关键在于通过众多组成成分在一系列空间和时间尺度上的相互作用而产生的系统动力学。在这里，我们专注于几个可以应用理论方法的组成部分，包括血管结构和力学、血流和质量传递、流量调节、血管生成和血管重塑以及血管细胞力学。对于每个组成部分，我们总结了模型开发的最新进展，并讨论了需要进一步研究的领域。我们强调了整合组件模型以开发计算工具的主要挑战，该工具最终可用于模拟冠状动脉系统对需求变化以及疾病和治疗的反应。
