Dhabhai Ravindra, Kalla G, Singhi M K, Ghiya B C, Kachhawa Dilip
Departments of Skin and V. D., Dr. S. N. Medical College, Jodhpur, Rajasthan, India.
Indian J Dermatol Venereol Leprol. 2005 Jan-Feb;71(1):9-13. doi: 10.4103/0378-6323.13778.
Therapy systemic lupus erythematosus (SLE) has been generally discouraging. Methyl-prednisolone pulse therapy has been used for various connective tissue disorders. We used intravenous dexamethasone cyclophosphamide pulse therapy to treat SLE.
Fourteen patients (10 females and 4 males) between the age of 15-48 years with definite or classical clinical criteria laid by American Rheumatism Association criteria were treated by Dexamethasone-Cyclophosphamide pulse (DCP) therapy at our center.
It was possible to induce a complete clinical remission with DCP therapy in most of the patients thereby offering them life free from disease and drugs. The side effects commonly observed with conventional daily dose regimen of corticosteroids were not present or were mild.
Almost all patients had good response after 3-4 pulses to allow them a normal life style. Fever, malar rash and oral ulceration responded early but photosensitivity, discoid rash, alopecia and joint pains took some more time.
系统性红斑狼疮（SLE）的治疗效果通常不尽人意。甲基泼尼松龙脉冲疗法已用于多种结缔组织疾病。我们采用静脉注射地塞米松环磷酰胺脉冲疗法治疗SLE。
我们中心对14例年龄在15至48岁之间、符合美国风湿病学会标准确定的或典型临床标准的患者（10例女性，4例男性）采用地塞米松 - 环磷酰胺脉冲（DCP）疗法进行治疗。
多数患者通过DCP疗法可实现完全临床缓解，从而使他们摆脱疾病和药物，过上正常生活。常规每日剂量皮质类固醇疗法常见的副作用不存在或很轻微。
几乎所有患者在3 - 4次脉冲治疗后反应良好，能够过上正常生活。发热、颧部红斑和口腔溃疡早期即有反应，但光敏性、盘状红斑、脱发和关节疼痛则需要更长时间恢复。
