自体黑素细胞移植治疗稳定期白癜风的研究
A study of autologous melanocyte transfer in treatment of stable vitiligo.
作者信息
Pandya Vishvabhavan, Parmar Kirti S, Shah Bela J, Bilimoria F E
机构信息
Department of Dermatology, Civil Hospital and BJ Medical College, Ahmedabad, India.
出版信息
Indian J Dermatol Venereol Leprol. 2005 Nov-Dec;71(6):393-7. doi: 10.4103/0378-6323.18942.
BACKGROUND
Replenishing melanocytes selectively in vitiliginous macules by autologous melanocytes is a promising treatment. With expertise in culturing melanocytes, it has now become possible to treat larger recipient areas with smaller skin samples.
AIM
To study the extent of repigmentation after autologous melanocyte transplantation in patients with stable vitiligo.
METHODS
The melanocytes were harvested as an autologous melanocyte rich cell suspension from a donor split thickness graft. Melanocyte culture was performed in selected cases where the melanocyte cell count was insufficient to meet the requirement of the recipient area. These cells were then transplanted to the recipient area that had been superficially dermabraded.
RESULTS
An excellent response was seen in 52.17% cases with the autologous melanocyte rich cell suspension (AMRCS) technique and in 50% with the melanocyte culture (MC) technique.
CONCLUSION
Autologous melanocyte transplantation can be an effective form of surgical treatment in stable but recalcitrant lesions of vitiligo.
背景
通过自体黑素细胞选择性补充白癜风斑中的黑素细胞是一种很有前景的治疗方法。随着培养黑素细胞技术的成熟，现在有可能用更小的皮肤样本治疗更大的受区。
目的
研究稳定期白癜风患者自体黑素细胞移植后的色素恢复程度。
方法
从供体断层皮片中获取富含自体黑素细胞的细胞悬液。在黑素细胞计数不足以满足受区需求的选定病例中进行黑素细胞培养。然后将这些细胞移植到已进行浅表磨皮的受区。
结果
富含自体黑素细胞的细胞悬液（AMRCS）技术在52.17%的病例中显示出良好的反应，黑素细胞培养（MC）技术在50%的病例中显示出良好的反应。
结论
自体黑素细胞移植可以成为稳定期但顽固的白癜风皮损的一种有效手术治疗方式。
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