Singh Harshvardhan, Yadav Chinmai, Singrodia Rahul, Kachhawa Dilip, Rao Pankaj
Department of Dermatology, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.
Department of Dermatology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
J Cutan Aesthet Surg. 2024 Jul-Sep;17(3):239-245. doi: 10.25259/jcas_152_22. Epub 2024 Aug 29.
This study aimed to evaluate the efficacy of autologous non-cultured non-trypsinized melanocytekeratinocyte grafting (JT) with suction blister membrane as biological dressing in stable vitiligo patches.
The study was conducted at Mathura Das Mathur Hospital (MDM), Jodhpur, on 43 patches of Stable vitiligo. It was a prospective single-arm interventional study. All patients were examined clinically and history and informed consent were taken before starting the procedure.
About 95% of patches showed >50% repigmentation with 83.72% having good to excellent repigmentation. About 88% of patches showed good color matches with an excellent decline in Dermatology Life Quality Index (DLQI). No serious complication was observed in the present study. The most common complication observed both in the donor and recipient area was pain.
Our study indicates that combining JT with suction blister epidermal grafting is a comparatively effective technique in terms of good repigmentation (≥75% extent of repigmentation), color match, fewer side effects, good patient satisfaction, and DLQI reduction.
本研究旨在评估以自体非培养非胰蛋白酶化黑素细胞 - 角质形成细胞移植（JT）联合吸引水疱膜作为生物敷料治疗稳定期白癜风斑块的疗效。
本研究在焦特布尔的马图拉·达斯·马图尔医院（MDM）对43处稳定期白癜风斑块进行。这是一项前瞻性单臂干预性研究。所有患者均接受临床检查，在开始治疗前采集病史并获取知情同意书。
约95%的斑块色素再生>50%，其中83.72%色素再生良好至极佳。约88%的斑块颜色匹配良好，皮肤病生活质量指数（DLQI）显著下降。本研究未观察到严重并发症。在供体和受体区域观察到的最常见并发症是疼痛。
我们的研究表明，就色素再生良好（色素再生程度≥75%）、颜色匹配、副作用较少、患者满意度高以及DLQI降低而言，JT联合吸引水疱表皮移植是一种相对有效的技术。
