Shangguan Wang Ning, Lian QingQuan, Aarons Leon, Matthews Ivan, Wang Zengshou, Chen Xiaolin, Freemantle Nick, Smith Fang Gao
Department of Anesthesiology, 2nd Affiliated Hospital of WenZhou Medical College, China.
Anesthesiology. 2006 Jan;104(1):27-32. doi: 10.1097/00000542-200601000-00006.
There is no information about the pharmacokinetic profile of propofol in Chinese children younger than 3 yr. This study was designed to determine a complete pharmacokinetic profile of a single dose of propofol in Chinese children of different ages.
Arterial blood samples were obtained from 35 children with an American Society of Anesthesiologist physical status of I or II at 2, 4, 6, 8, 10, 20, 30, 45, 60, 90, 120, and 180 min after a single bolus intravenous injection of propofol (3 mg/kg). The plasma concentrations of propofol were measured using high-performance liquid chromatography with an ultraviolet detector. A population model was used to estimate the pharmacokinetics of propofol.
A three-compartment pharmacokinetic model best described the pharmacokinetics of propofol. Clearance was 0.185 l/min, the volume of distribution of the central compartment was 7.41 l, the peripheral volumes of distribution were 54.6 and 7.2 l, and the intercompartmental clearances were 0.614 and 0.692 l/min for a child of the average weight of 13.7 kg. The half-lives were 2.67, 14.89, and 310.60 min. Covariate models were applied, and weight was found to be significant covariate for the clearance and volume of distribution parameters. No significant age effect could be demonstrated on clearance or volume of distribution parameters after weight was taken into account.
This study supports the case that the pharmacokinetic properties of propofol do not differ substantially across Chinese children of different ages after weight has been accounted for.
关于丙泊酚在中国3岁以下儿童中的药代动力学特征尚无相关信息。本研究旨在确定单剂量丙泊酚在中国不同年龄段儿童中的完整药代动力学特征。
对35例美国麻醉医师协会身体状况分级为I或II级的儿童，单次静脉推注丙泊酚（3mg/kg）后，于2、4、6、8、10、20、30、45、60、90、120和180分钟采集动脉血样本。采用高效液相色谱-紫外检测器法测定丙泊酚的血浆浓度。使用群体模型估算丙泊酚的药代动力学。
三室药代动力学模型能最好地描述丙泊酚的药代动力学。对于平均体重为13.7kg的儿童，清除率为0.185l/min，中央室分布容积为7.41l，外周分布容积分别为54.6l和7.2l，室间清除率分别为0.614l/min和0.692l/min。半衰期分别为2.67、14.89和310.60分钟。应用协变量模型，发现体重是清除率和分布容积参数的显著协变量。在考虑体重因素后，未发现年龄对清除率或分布容积参数有显著影响。
本研究支持以下观点，即考虑体重因素后，丙泊酚在中国不同年龄段儿童中的药代动力学特性无显著差异。
